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  • Roles of Sex Hormones and Gender in the Gut Microbiota

    Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16

  • Variations in Clinical Practice of Esophageal High-resolution Manometry: A Nationwide Survey

    Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.

  • Normal Values of High-resolution Manometry Parameters With Provocative Maneuvers

    High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.

  • Rectosigmoid Localization of Radiopaque Markers for Identifying Defecation Disorders in Patients With Chronic Constipation: A Retrospective Cohort Study

    Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.

  • Inter-hemispheric Functional Connections Are More Vulnerable to Attack Than Structural Connection in Patients With Irritable Bowel Syndrome

    Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs; P < 0.05, corrected with Alphasim). IBS patients showed much higher VMHC in superior occipital gyrus, middle occipital gyrus, precuneus, posterior cingulate gyrus, and angular gyrus (red), while lower in supplementary motor area (blue). The color bar indicates the T-value from t test between groups.

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J Neurogastroenterol Motil 2021; 27(3): 307~443 Total PDF
Editorials
Analysis of Whole Gut Motility for the Evaluation of Diabetic Gastroenteropathy: Still the Road Untraveled?
Eun Jeong Gong
J Neurogastroenterol Motil 2021; 27(3): 307-309  https://doi.org/10.5056/jnm21114
Role of Bile Reflux in Functional Dyspepsia: Areas That Need Further Research
Seung Joo Kang
J Neurogastroenterol Motil 2021; 27(3): 310-311  https://doi.org/10.5056/jnm21112
Is There a Role for Radiopaque Markers in Identifying Defecation Disorders?
Yoo Jin Lee
J Neurogastroenterol Motil 2021; 27(3): 312-313  https://doi.org/10.5056/jnm21115
Reviews
Roles of Sex Hormones and Gender in the Gut Microbiota
Kichul Yoon and Nayoung Kim
J Neurogastroenterol Motil 2021; 27(3): 314-325  https://doi.org/10.5056/jnm20208
DLMPT LED Ring Make Up Light with Tripod Ringlight Make Up Light
Kwang Jae Lee
J Neurogastroenterol Motil 2021; 27(3): 326-336  https://doi.org/10.5056/jnm21042
LKBEADS 1 Strand Natural Pink Sapphire 3 to 6MM Faceted Rondelle
Srikant Mohta, Mahendra S Rajput, Vineet Ahuja, and Govind K Makharia
J Neurogastroenterol Motil 2021; 27(3): 337-346  https://doi.org/10.5056/jnm20140
Original Articles
Variations in Clinical Practice of Esophageal High-resolution Manometry: A Nationwide Survey
Eun Jeong Gong, Soo In Choi, Bong Eun Lee, Yang Won Min, Yu Kyung Cho, Kee Wook Jung, Ji Hyun Kim, and Moo In Park; Dysphagia Study Group Under the Korean Society of Neurogastroenterology and Motility
J Neurogastroenterol Motil 2021; 27(3): 347-353  https://doi.org/10.5056/jnm20217
Normal Values of High-resolution Manometry Parameters With Provocative Maneuvers
Hui Su, Amanda J Krause, Melina Masihi, Jacqueline Prescott, Alex Decorrevont, Emma Germond, Dave Karasik, Wenjun Kou, John E Pandolfino, and Dustin A Carlson
J Neurogastroenterol Motil 2021; 27(3): 354-362  https://doi.org/10.5056/jnm20118
Upright Integrated Relaxation Pressure Predicts Symptom Outcome for Esophagogastric Junction Outflow Obstruction
Songfeng Chen, Mengya Liang, Niandi Tan, Mengyu Zhang, Yuqing Lin, Peixian Cao, Qianjun Zhuang, and Yinglian Xiao
J Neurogastroenterol Motil 2021; 27(3): 363-369  https://doi.org/10.5056/jnm20106
Evaluations of Gastric Acid Pocket Using Novel Vertical 8-Channel pH Monitoring System and Effects of Acid Secretion Inhibitors
Shohei Sumi, Norihisa Ishimura, Hironobu Mikami, Eiko Okimoto, Yuji Tamagawa, Tsuyoshi Mishiro, Yoshikazu Kinoshita, and Shunji Ishihara
J Neurogastroenterol Motil 2021; 27(3): 370-376  https://doi.org/10.5056/jnm20115
The Reflux Symptoms Before and After Peroral Endoscopic Myotomy of Chinese Patients With Achalasia
Ying Xu, Yan Wang, Yun Bao, Ting Yu, Yurong Tang, Lin Lin, and Liuqin Jiang
J Neurogastroenterol Motil 2021; 27(3): 377-389  https://doi.org/10.5056/jnm20041
Gastric Emptying Time and Volume of the Small Intestine as Objective Markers in Patients With Symptoms of Diabetic Enteropathy
Mette W Klinge, Nanna Sutter, Esben B Mark, Anne-Mette Haase, Per Borghammer, Vincent Schlageter, Sten Lund, Jesper Fleischer, Karoline Knudsen, Asbjørn M Drewes, and Klaus Krogh
J Neurogastroenterol Motil 2021; 27(3): 390-399  https://doi.org/10.5056/jnm19195
Bile Reflux Gastropathy and Functional Dyspepsia
Andrew Lake, Satish S C Rao, Sebastian Larion, Helena Spartz, and Sravan Kavuri
J Neurogastroenterol Motil 2021; 27(3): 400-407  https://doi.org/10.5056/jnm20102
Predictors of Early Readmissions in Hospitalized Patients With Gastroparesis: A Nationwide Analysis
Ravi B Pavurala, Peter P Stanich, Somashekar G Krishna, Praveen Guturu, Alice Hinton, Darwin L Conwell, and Gokulakrishnan Balasubramanian
J Neurogastroenterol Motil 2021; 27(3): 408-418  https://doi.org/10.5056/jnm20105
Rectosigmoid Localization of Radiopaque Markers for Identifying Defecation Disorders in Patients With Chronic Constipation: A Retrospective Cohort Study
Tatsuya Abe, Masao Kunimoto, Yoshikazu Hachiro, Kei Ohara, Mitsuhiro Inagaki, and Masanori Murakami
J Neurogastroenterol Motil 2021; 27(3): 419-425  https://doi.org/10.5056/jnm20204
6 Sheets Big Sunflower Butterfly Wall Decal Peel and Stick Sunfl
Guangyao Liu, Shan Li, Nan Chen, Ziyang Zhao, Man Guo, Hong Liu, Jie Feng, Dekui Zhang, Zhijun Yao, and Bin Hu
J Neurogastroenterol Motil 2021; 27(3): 426-435  https://doi.org/10.5056/jnm20134
Letter to the Editor
A Novel Cohesinopathy Causing Chronic Intestinal Pseudo Obstruction in 2 Siblings and Literature Review
Vybhav Venkatesh, Aradhana Aneja, Keerthivasan Seetharaman, Neha Anushree, Surinder S Rana, and Sadhna B Lal
J Neurogastroenterol Motil 2021; 27(3): 436-437  https://doi.org/10.5056/jnm20259
Metastatic Intrahepatic Cholangiocarcinoma Presenting as an Achalasia-like Syndrome
Catarina Gomes, João Correia, Ana Ponte, Edgar Afecto, Rolando Pinho, and João Carvalho
J Neurogastroenterol Motil 2021; 27(3): 438-439  https://doi.org/10.5056/jnm21035
Erratum, Corrigendum, and Addendums
Erratum
J Neurogastroenterol Motil 2021; 27(3): 440-440  https://doi.org/10.5056/jnm20051E
Corrigendum
J Neurogastroenterol Motil 2021; 27(3): 441-442  https://doi.org/10.5056/jnm20014C
Addendum
J Neurogastroenterol Motil 2021; 27(3): 443-443  https://doi.org/10.5056/jnm18029A

  • News & Notice
  • Tae Hee Lee
    Institute for Digestive Research, Soonchunhyang University Seoul Hospital, Seoul, Korea
    Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary’s hospital, Seoul, Korea
  • Jung Ho Park
    Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
  • Kewin T H Siah
    Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore
The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. Mozart Brahms: Clarinet Quintet

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Neurogastroenterology and Motility Societies in the World